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investigation 123 (9), 36783684

Acute feedback control of astrocytic glycolysis by lactate

Mechanistically, BDH1 reduced H3K9 -hydroxybutyrylation at the LCN2 promoter, suppressed LCN2 transcription and NF-B activation, while treatment with the -hydroxybutyrylation inhibitor A485 similarly alleviated the cardiac damage [134]