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Catching up on sleep, such as by sleeping late on weekends, appears to mitigate, though may not completely reverse, some of the negative health effects of sleep loss

Whether these mutations have a causative or associative role in the ASD phenotype remains to be determined

These endocrine abnormalities if not treated, culminate to metabolic syndrome development, in which the key pathophysiological components include abdominal fat accumulation, reduced systemic insulin sensitivity, low-grade inflammation, high blood pressure, high blood sugar levels, high triglyceride levels, and low levels of high-density lipoprotein (HDL) cholesterol [2]