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The limited absorption of the nasal cavity restricts the amount of drug being effectively absorbed, making class I drugs (high permeability, high solubility), according to the Biopharmaceutics Drug Disposition Classification System (BDDCS), particularly suitable for nasal delivery (Ugwoke et al., 2001)

For example, this should include time-of-day chronotherapeutic studies that examine whether exogenous melatonin is most beneficial to be given to patients in relation to endogenous rhythms

Taking enough sleep (7-9 hours) enables our body to maintain a good antioxidant balance

THANK YOU Susan Halpern 9 years ago Many thanks to Dr