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4.6.6 Hazel leaf polyphenol extract Sun et al.s study (Sun et al., 2024) illustrated that cisplatin-induced ferroptosis leads to damage of renal tubular cells and renal dysfunction, which is associated with increased phosphorylation of yes-associated protein

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Interestingly, selenium deficiency in rodents was found to have little impact on DIO activities as it appears that selenium is being supplied in priority for adequate synthesis of DIOs at the expense of other selenoenzymes (10)

With respect to bioenergetics, substantial depletion of intracellular ATP in BJeLR and HT-1080 cells treated with H 2 O 2 , but not erastin, STS or rapamycin, was observed ( FIG