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It interacts with polyglutamine-expanded huntingtin protein, promoting clearance through autophagy and SIRT1-mediated pathways

The observation that the earliest atherosclerotic lesions characteristically form in regions of arterial bifurcation, oscillatory shear stress, and turbulent flow has long been appreciated, in contrast to uniform, tubular regions which are relatively protected from atherogenesis ( Signal transduction of shear stresses experienced by the endothelium are initiated by mechanosensitive elements including integrins, G-protein coupled receptors, cytoskeletal sensors, junctional proteins, and the endothelial glycocalyx, among others (Parmar et al., 2006)

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Several studies have shown that BEC plasticity, which includes the dedifferentiation of BECs into bipotential progenitor cells and the subsequent transformation of progenitor cells into hepatocytes, is essential for liver regeneration