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Repeated administration via nasal or intravenous routes remains safe, which is critical for managing chronic diseases such as AD [53]

R.OldenhuisC

However, in Lewy body disease with comorbid AD, Lewy-related pathology in the amygdala is found from an early stage and even in the absence of Lewy-related pathology in the brainstem [192, 193, 334]

Notably, supplementation with ferrostatin-1 or trolox, both of which are radical-trapping antioxidants and potent inhibitors of ferroptosis, rescued survival but not proliferation under cystine-free conditions (Extended Data Fig