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MDM2 is well known to strictly control p53

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Many ocular manifestations of glaucoma (IOP changes, calcium overloads, reactive gliosis, cytokine release, microvascular dysfunction, actin upregulation, fibronectin secretion and RGC apoptosis) can be mimicked pharmacologically by stimulating TRPV4 channels in RGCs, glial, endothelial, ciliary body and trabecular meshwork cells (27, 111, 127, 133)

In the American Time Use Survey data (20032018) representing the United States, eating/drinking less than 1 hour before bedtime appears to be associated with longer sleep duration while also increasing the likelihood of wake after sleep onset (WASO)