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Unstable iron (mainly in the form of ferrous iron) can react with oxygen and produce ROS, such as hydroxyl radicals and hydrogen peroxide, which are related to lipid peroxidation and tissue damage induced through the Fenton reaction

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In aggregate, recent studies further support the association between elevated GGT activity and the risk of incident T2D and lay the foundations for monitoring and lowering GGT levels as a reasonable public health target for T2D prevention

Puerarin, isolated from Pueraria lobata (Willd.), protects against diabetic nephropathy by attenuating oxidative stress