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Quantitative real-time PCR (Q-PCR) analyses also revealed downregulation of Prx3 in spinal cords of sALS and mutant SOD1 ALS patients, suggesting loss of redox regulation and these antioxidant defense mechanisms in ALS (Wood-Allum et al., 2006)

Then we clarified the mechanisms of GH-IGF1 signaling in radio-resistance and tissue damage repair by its roles in promoting cell proliferation and attenuated apoptosis, as well as the critical DNA damage repair

This also affects the phagocytotic activity of macrophages