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Cell (2017) 10.1016/j.cell.2017.02.031 The seminal paper demonstrating FOXO4-DRI's mechanism and efficacy

For example, CAN often presents with resting tachycardia and orthostatic hypotension, so nonpharmacologic strategies (such as adequate salt intake and physical activities and avoidance of medicine-related hypotension) and pharmacologic strategies (such as midodrine and droxidopa) should be considered to minimize postural symptoms rather than to restore normotension

Therefore, the complex molecular characteristics aim to provide accurate treatment for each patient

The beneficial effects of probiotics on infertility associated with stress have been attributed to various mechanisms, such as regulating the HPA axis, modulation of the immune response, and restoring microbial homeostasis (184)