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shows that 7nAChRs knockout mice that do not respond to cholinergic agonists, which in turn enhance the production of several cytokines and inflammatory markers, including tumor necrosis factor-alpha (TNF-) and interleukin-1 (IL-1) [65], this results from suppression of signal transduction cascade including PIK3/Akt and Nrf2 and upregulation of NF-B that represent a transcriptional factor capable of coordinating the inflammatory response, regulating the inflammatory gene expression [35, 66]

Li Y, Sheng L, Li W, Liu W, Gong Y, Xue H, et al

Bin Heyat MB, Akhtar F, Khan A, Noor A, Benjdira B, Qamar Y, Abbas SJ, Lai D (2020) A novel hybrid machine learning classification for the detection of bruxism patients using physiological signals