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doi: 10.1038/ncomms13666 26 OrentreichN.MatiasJ

Almost all patients report a local inflammatory response, which is reversible following discontinuance of topical treatment

In addition, cumulative evidence suggests that KOA as a metabolic disorder also requires energy metabolic pathways to meet the demands of tissue repair

Antioxidant capacity in the lung is substantially reduced and oxidative stress can persist long after the cessation of cigarette smoking or an acute exacerbation of COPD owing to continued production of ROS from endogenous sources [9, 12]