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GTP-bound RAS (activated form) binds to RAF proteins (c-RAF, BRAF, and ARAF) and induces conformational alternations to dimerize RAF, which is activated and turns on the kinase cascade [110]

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Innovation in Dual and Triple Agonist Therapies The fact that Cagrilintide and Semaglutide work well together supports the dual-agonist approach and encourages the creation of molecules that combine multiple receptor functions within a single peptide structure