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Statements Author contributions PL: Data curation, Investigation, Methodology, Writing original draft

British Journal of Dermatology , 142 (1), 44-51

while, miR-21, miR-27a, and miR-186 were found to improve chemosensitization toward chemotherapeutic agents [122, 123]

These agents in fact reacted adversely with cysteinyl residues in topoisomerase by using mutant yeast TOP2 with all cysteine residues replaced with alanine (cysteineless TOP2)