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Patients may reject drug therapy due to disbelief of the diagnosis, negative beliefs about treatment efficacy, fear of potential side-effects, mistrust of modern medicine or beliefs in self- or alternative treatment

YAP1 and NF1 were colocalized in both cells as calculated by Colocalization Finder in Image J

RA-FLSs have tumor cell-like anti-apoptotic characteristics, and inhibition of their proliferation and migration has been the focus of attention in RA therapy