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British Journal of Clinical Pharmacology, 53 (Suppl

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The incidence of cutaneous melanoma has increased rapidly worldwide.15 Although it corresponds to only 4% of all skin cancers, it accounts for 80% of skin cancer deaths.4 Because early detection of the disease is implicit in its cure and only 14% of patients with metastatic disease survive beyond 5 years,46 knowledge of factors that increase an individual's risk for developing melanoma and diagnosis at an early stage of the disease have great prognostic relevance