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Advanced symptoms of Parkinsons disease include: Uncontrollable shaking and tremors Reduced ability to chew and swallow Difficulty enunciating words Impaired ambulation and frequent falls Bent-over posture rinary and fecal incontinence nability to perform activities of daily living (ADL) like dressing, bathing, and eating As Parkinsons approaches its end game, palliative care and hospice with pain management are the final treatment approaches

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Sections were blocked with 2.5% normal horse serum (Vector Laboratories) for 1 h, followed by 24 h of incubation with the following rabbit primary antibodies: anti-S100 (1:100, Abcam ab41548), anti-MAOB (1:100, Abcam ab175136, Santacruz sc-515354), and anti-ABAT (1:100, Abcam ab108249)