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In a randomized controlled trial of 67 women, curcumin supplementation (500 mg three times daily for 12 weeks) significantly decreased fasting blood glucose and DHEA levels compared to placebo

Another study reported that weekly 50,000 IU vitamin D for 8 weeks, followed by daily oral supplementation with 2,500 mg calcium carbonate (1,000 mg elemental calcium) plus 9.68 mg cholecalciferol (880 IU vitamin D) for 3 months, significantly elevated SHBG levels and decreased TT, FT, and ADMA concentrations, effectively improving menstrual regularity and alleviating hirsutism in non-obese PCOS patients (116)

The number of variables randomly sampled as candidates at each split (two) and number of trees (500) were optimized after consecutive cross-validated training (5-fold cross-validation, repeated ten times)

Further research has suggested that it may also have cartilage anabolic effects and oral bioavailability that is rare among peptides