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Abbreviations A: Amyloid beta AD: Alzheimers Disease ALDH: Aldehyde Dehydrogenase ALDH1A1: Aldehyde Dehydrogenase 1 family member A1 BSA: Bovine Serum Albumin DAO: Diamine Oxidase DEAB: N,N-diethylaminobenzaldehyde DG: Dentate gyrus FPKM: Fragments per kilobase per million mapped fragments GABA: Aminobutyric acid GFAP: Glial Fibrillary Acid Protein HDAC: Histone Deacetylase HRP: Horseradish Peroxidase IHC: Immunohistochemistry LC/MS: Liquid Chromatography/Mass Spectrometry MAOB: Monoamine Oxidase B NGS: Next Generation Sequencing PBS: Phosphate Buffered Saline ROS: Reactive Oxygen Species shRNA: Short hairpin RNA SIRT: Sirtuin TBST: Tris buffered Saline Tween20 TG : Transgenic WT: Wild type References Chen Y, Qin C, Huang J, Tang X, Liu C, Huang K, et al

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Bayley EM, Zhou N, Mitchell KG, Antonoff MB, Mehran RJ, Rice DC , Sepesi B, Swisher SG, Vaporciyan AA, Walsh GL, Cinciripini PM, Karam-Hage M, Roth JA, Hofstetter WL

TABLE 3 Phosphorylation events regulating mitochondrial calcium homeostasis and MAMs