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Emerging clinical evidence indicates that serum CRP (human clinical study) is significantly increased in patients with DPN, 9193 while higher CRP level is inversely related to NCV ( P 0.8) in ROC analysis, supporting their potential use as non-invasive biomarkers

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In addition, the tricarboxylic acid cycle or electron transfer chain in the mitochondria can promote lipid ROS accumulation and is involved in cysteine-deprivation-induced ferroptosis [18]