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Description

The commonly found variants of this enzyme are P1173L and A2756G

Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate

P.BianY

This is likely a distinct pathway from PFKL-mediated suppression of PMA-induced NET formation, which operates by redirecting flow from the oxPPP to glycolysis 37 because HA-induced NET formation is not blocked by G6PD or NOX inhibitors