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In addition, it can inhibit the release of pro-inflammatory factors, interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-), through the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) signaling pathway to improve chronic inflammation (Ruiz-Ruiz et al., 2017)

Only 0.10.2% of total stores are lost daily through excretion

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Our study conceptualizes a dual mode of action by which metronidazole and 5-nitroimidazole ethers induce stress and simultaneously inhibit the stress response with deleterious effects on bacterial survival