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Park and Kim (2016) reported a meta-analysis on 1258 patients and 1573 controls confirming a significant association of GST-M1- and GST-T1-null genotypes with vitiligo (GST-M1 OR = 1.494, p = 0.005

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Metabolomics analyses revealed a time-dependent increase in tricarboxylic acid cycle intermediates during ES treatment, suggesting that copper toxicity primarily disrupts the tricarboxylic acid cycle rather than oxidative phosphorylation (180,181)