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Multiple NAFLD pathogenic mechanisms should not be viewed independently, as there may be ongoing crosstalk between different tissues or organs, where an intrinsic association of adipose tissue and the gut may contribute to NAFLD [49] because dysregulated intestinal metabolism contributes to fat accumulation and lipid deposition in the liver via the gut-adipose tissue-liver axis and mediates hepatic disease development [50]

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It contains sulfur in the form of sulfhydryl thiol form which is ionizable, forming a negatively charged thiolate group after deprotonation that further increases its reactivity