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Uric Acid Production as a Target of Therapy in Patients With Gout In the catabolism of purines, uric acid generation by the enzyme xanthine oxidase (that also has xanthine dehydrogenase activity) ( Figure 1 - 2 ) highlights the key therapeutic mechanisms of action of the xanthine oxidase inhibitors allopurinol and febuxostat ( Pharmacologic Urate-Lowering Therapy )

Baolin Qu, [email protected] These authors have contributed equally to this work This article was submitted to Molecular Diagnostics and Therapeutics, a section of the journal Frontiers in Molecular Biosciences Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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