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In osteoarthritis (OA), research has also demonstrated that IgE-mediated mast cells can be activated via FcRI and Syk, leading to mast cell degranulation and the release of pro-inflammatory factors and cartilage-degrading mediators (including tryptase), resulting in cartilage and joint destruction and aggravating OA cartilage damage (132)

Epigenetical targeting of the FOXP3 Gene by S-adenosylmethionine diminishes the suppressive capacity of regulatory T cells ex vivo and alters the expression profiles