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Compared to the intracellular phagosomal space where the substrate availability is controlled, the MPO-dependent oxidative biochemistry in the extracellular environment is usually far more diverse, leading to substantial modifications of a wide variety of biomolecules, including DNA, lipids, carbohydrates and proteins

CrossRef Xanthine oxidase inhibition by febuxostat attenuates stress-induced hyperuricemia, glucose dysmetabolism, and prothrombotic state in mice Maimaiti Yisireyili, Motoharu Hayashi, Hongxian Wu, Yasuhiro Uchida, Koji Yamamoto, Ryosuke Kikuchi, Mohammad Shoaib Hamrah, Takayuki Nakayama, Xian Wu Cheng, Tadashi Matsushita, Shigeo Nakamura, Toshimitsu Niwa, Toyoaki Murohara, Kyosuke Takeshita Scientific Reports.2017;[Epub] CrossRef Differential Effect of Sucrose and Fructose in Combination with a High Fat Diet on Intestinal Microbiota and Kidney Oxidative Stress Adriana Rosas-Villegas, Mnica Snchez-Tapia, Azalia Avila-Nava, Victoria Ramrez, Armando Tovar, Nimbe Torres Nutrients.2017

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Notably, herein, we found that NACET maintained its capability to protect cells against oxidative stress even when pretreatment was followed by extensive washing, suggesting that NACET increases the internal defense mechanisms of RPE cells to cope with oxidative stress