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It is found that the the thyroid gland, which exhibits the highest selenium concentration per unit of tissue, remarkably retains selenium and continues to express selenoproteins even in the face of severe selenium deficiency, reflecting the distinctiveness of the human thyroid and highlights the critical importance of selenium for its proper functioning and health (8688)

The plate was then washed, followed by the addition of anti-human IgG Fc conjugated to HRP (Invitrogen) and incubation for 2 h at room temperature

This blockage in autophagic flux ultimately leads to BAX/BAK oligomerization, activation of Caspase-3-mediated apoptosis, as verified in a POF model rat (Zhou et al., 2023)