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This conservative protocol prioritizes long-term safety while still achieving meaningful telomerase activation

The tumor regrowth rechallenge performed after day 94 of the study confirmed that F-LALA-VA-EXA is able to induce a protective immunologic memory response, as no tumor growth was observed after re-implantation of the groupe treated with F-LALA-VA-EXA at 12mg/kg IV once (a positive control group with new untreated SCID mice showed tumor growth after implantation)

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Critical challenges included insufficient sample size reducing statistical power, reliance on self-reported exposure data introducing recall bias, and inadequate control for confounding factors such as smoking and alcohol consumption