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and the reduction of leukocyte adhesion ( Betaine is a methyl derivative of glycine that is primarily obtained from dietary sources but is also endogenously synthesized in the liver from choline ( Betaine is stored in the kidney and liver, and serves three important physiological functions: it acts as an osmolyte that regulates cell volume, it acts as a chemical chaperone that protects against protein degradation, and it serves as a methyl donor in the methionine cycle which detoxifies homocysteine to methioninea process that is crucial for numerous cellular functions ( Although homocysteine is commonly associated with cardiovascular diseases, there is increasing evidence supporting its strong correlation with CKD and renal injury (Shih et al., 2022

Vitamin B12 is an essential nutrient that plays a critical role in maintaining overall health and well-being

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