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By binding with IGF-1, IGF-2, and insulin, IGF-1R activates downstream pathways including phosphoinositide 3 kinase (PI3K)/AKT and Ras/extracellular signal-regulated protein kinase (ERK) pathways, 1 two frequently activated pathways in colorectal cancer

CBD increases mitochondrial membrane permeability, leading to cytochrome c release and the activation of extrinsic apoptotic pathways [31]

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