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Geier, B., Kurmashev, D., Kurmasheva, R

Metabolic reprogramming from glycolysis to fatty acid uptake and beta-oxidation in platinum-resistant cancer cells

the present inventors recognize two additional limitations in the use of artificially split-inteins: they (1) are less active than their continuous counterparts due in part to a lower affinity between the split fragments, and (2) have a high tendency to form aggregates when expressed alone