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B., Wall, B

401 Additionally, the adoptive transfer of in vitro expanded or genetically engineered CD4 + T cells has emerged as a promising therapeutic approach to rejuvenating immune function in the context of immunosenescence

In vitro studies have shown that Lactobacillus promotes the proliferation and migration of intestinal epithelial cells, regulates the expression of tight junction proteins claudin-1 and occludin, reduces paracellular permeability, and prevents the nuclear translocation of NF-B p65 in intestinal epithelial cells, thereby inhibiting the release of proinflammatory cytokines TNF- and IL-1 (107, 108)

where 0.4368 is the average value of E 2( t ) during the cycle (calculated from Panel A of Figure 2)