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My main messages were: Cardiometabolic Diseases appear as a syndromic cluster at the individual level, but at a population level they are very different: CVD is a 'tame' problem (huge declines in HICs over 50y) whereas obesity/diabetes is a 'wicked' problem (all countries increasing over 50y)

Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition

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This, in turn, permits the inclusion of native Levo (L isomer) and/or non-native Dextro (D isomer) glutamic acid and/or cysteine derivatives or residues within any of these compounds