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doi: 10.1152/ajpregu.00280 44 PinALHouleFGuillonneauMPaquetERSimardMJHuotJ

In contrast, during acute ethanol exposure, ethanol competes with APAP for Cyp2E1 metabolism, which reduces NAPQI formation as long as ethanol is present and attenuates liver injury [176]

A factual note on regulatory status: both semaglutide and tirzepatide are approved prescription drugs in various jurisdictions for clinical indications, but in the Canadian research-supply context they are sold strictly as research-grade compounds and are not approved by Health Canada for the research uses discussed here