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Consequently, small-molecule inhibitors that block Munc13-4STX7 binding are not expected to disrupt Munc13-4 interactions with exocytosis mediators or its role in granule docking at the plasma membrane

When targeted with a monoclonal antibody against cis p-tau, neuronal apoptosis was prevented, suggesting that accumulation of cis p-tau is very early in the pathogenic sequence of post-TBI neurodegeneration (94)

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