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Researchers designing protocols based on this escalation data should reference the published Phase 2 data while monitoring Phase 3 publications for refinements

In adults, somatomedin alteration contributes to increased osteoclast activity, resulting in weaker bones that are more prone to pathologic fracture and osteoporosis

These findings suggest that targeted inhibition of CD38 ecto-enzymatic activity could be a potential pharmacological approach for SSc fibrosis treatment