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Byrns, C

GLS activity is regulated by several factors: Cytokines and Growth Factors: In cancer cells, growth factors such as epidermal growth factor (EGF) or insulin-like growth factor (IGF) activate the PI3K-AKT pathway, which enhances GLS expression and activity

However, such combination therapies come with challenges

Therefore, further prospective studies are warranted to elucidate the potential therapeutic value of these agents in addressing COVID-19-related insulin resistance