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Interestingly, multiple transcription factors, such as Myc, Wnt, and hypoxia inducible factors, can cause a transcriptional increase of one or more PDK isoforms in a cancer cell

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Of note, a growing number of studies support mitochondrial metabolism of LAC as a common culprit underlying psychiatric and neurodegenerative diseases such as MDD and AD as well as obesity, making it important to further understand mechanisms for the development of aberrant mitochondrial metabolism of LAC