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We found that the cells form the TARDBP family have an impaired defense system against oxidative stress, with lower glutathione levels respect to the unrelated CTRLs, suggesting reduced abilities to cope with oxidative stress, which may account for the increase in ROS levels, despite the upregulation of SOD2 expression in patients cells

Open questions Inflammation has an impact on ferroptosis, but what precisely is the underlying mechanism

SIRT5 functions as a global regulator of mitochondrial lysine succinylation and involved in metabolic regulation [124]