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Description

In vivo testing in xenograft mouse models confirmed that UCM 1037 suppressed DX3 tumor growth and demonstrated greater inhibitory activity compared to melatonin alone at the same dose (16 mg/kg) [87]

Various aspects of CDDP resistance have been uncovered by proteomic approaches

Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds