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Secondary endpoints included a comparison of the plasma levels of profibrotic factor osteopontin (OPN, also known as SPP1) and antioxidant enzyme paraoxonase (PON1) as arylesterase activity, Hematoxylin and Eosin (H&E) muscle histology, region-of-interest (ROI)-quantitative measurement of percentage gadolinium-enhanced muscle areas using magnetic resonance imagine (MRI) (Voisin et al., 2005) and functional measures including voluntary running (cumulative distances), time (min) to exhaustion running downhill and spontaneous cage activity (beam break counts)

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Besides producing energy our mitochondria are the greatest producers of free radicals in the body

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