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doi: 10.1002/pro.4150

This dysregulation is partially mediated by alterations in the NKCC1/KCC2 expression ratio, which governs intracellular chloride gradients and GABAergic polarity (see Section 'Disruption of Neurotransmitter Balance by Anesthetics'), as well as through direct interference with the functional integrity of GABA A Rs and NMDA receptors (Cabrera et al