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In this study, FKB targeted TLR2 to inhibit the formation of the TLR2-MyD88 complex, thereby suppressing the NF-B signaling pathway both in vivo and in vitro

Biomedicine & Pharmacotherapy, 97 , 958-968

This process is driven by the accumulation of ROS and the peroxidation of polyunsaturated fatty acids in cellular membranes, leading to the formation of lipid hydroperoxides that compromise membrane integrity and cause cell swelling and death