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6.2 Probiotics, prebiotics, synbiotics, and postbiotics Probiotics are live microorganisms that colonize the human and animal intestines, maintaining the balance of the hosts intestinal microbiota and exerting beneficial effects on the hosts health (Mazziotta et al., 2023)

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Hepatic insulin resistance Hepatic insulin resistance is the key pathophysiological event during the development of T2DM and NAFLD, which is characterized by suppressed glycogenesis, increased gluconeogenesis and glycogenolysis, and augmented de novo lipogenesis (62-64)