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Major cell populations within the pancreatic islet were identified based on their characteristic gene expression profiles, including endocrine cells (, , , and Pp), exocrine cells (acinar and ductal), and other known cell types (mesenchymal, endothelial, immune, and stellate) (Supplementary Fig

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More likely than not, she is given estrogen only (such as Premarin), setting up an unopposed estrogen environment