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GHK-Cu modulates the expression of over 4,000 human genes (31.2% of the genome), activating 1,942 genes (including 47 DNA repair genes) and suppressing 762 genes

Comprehensive Skin Improvements The mechanisms produce: Increased Skin Thickness Both epidermis and dermis show measurable thickening, reversing age-related thinning Improved Hydration Enhanced glycosaminoglycan production creates better moisture retention Significant Smoothing Collagen synthesis stimulation reduces wrinkle depth and surface irregularities Increased Elasticity Elastin production enhancement restores youthful bounce and firmness Improved Contrast (Evenness) Reduced hyperpigmentation and more uniform skin tone Enhanced Collagen I Production The primary structural collagen increases substantially Tightened Loose Skin Matrix remodeling restores structural support Barrier Protein Repair Protective skin barrier proteins receive restoration Photodamage Reduction Mottled hyperpigmentation shows correction Photoaging Protection Photoaging protection includes keratinocyte protection from lethal UV-B radiation and blocking UV-induced erythema without increasing UV sensitivity

My esthetician noticed on her own without me bringing it up, and that was the confirmation I needed

Proc Natl Acad Sci U S A, 2003