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While treatment with rhGH in normal mice increases body weight, lean body mass, and liver weight but does not increase hepatic expression and release of IGF1, suggesting IGF1 is not a reliable indicator of the biological effects of exogenous GH treatment in genetically and pharmacologically unmodified individuals (Yamauchi and Pessin, 1994

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Hereditary haemoglobinopathies and bone marrow failure syndromes have been associated with hypothalamicpituitarygonadal axis dysfunction, hypogonadism, and abnormal sperm parameters