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By incorporating ginsenosides Rh1 and Rh2 into self-microemulsifying systems (SME-1 and SME-2) containing intestinal cytochrome P450, P-glycoprotein inhibitory excipients, and only P-glycoprotein inhibitory excipients, the uptake of Rh1 and Rh2 by Caco-2 cells is increased by 1.69-fold and 1.62-fold, and 1.79-fold and 1.82-fold respectively compared with the free components