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In the 5xFAD mouse model, reduced secretion of Brain-Derived Neurotrophic Factor (BDNF) from astrocytes results in a 30% decrease in neuronal dendritic spine density and impaired cognitive function

Science and Technology Development Plan Project of Jilin Province, China (20240601022RC) Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest

AEs included increased serum creatinine (some cases managed by adjusting dose downward), hypertension (managed with anti-hypertensive meds), alopecia, cutaneous lymphoma, mouth ulcers, and acute gout (managed with allopurinol)